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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Oaz3tm1Htan
targeted mutation 1, Hiromitsu Tanaka
MGI:4462794
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Oaz3tm1Htan/Oaz3tm1Htan involves: 129S1/Sv * C57BL/6 MGI:4462795


Genotype
MGI:4462795
hm1
Allelic
Composition
Oaz3tm1Htan/Oaz3tm1Htan
Genetic
Background
involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oaz3tm1Htan mutation (2 available); any Oaz3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• Separation of the sperm head and tail was observed in spermatozoa in the cauda epididymis
• the capitulum and striated columns were not apparent in the cytoplasm of the separated head
• almost all of the sperm heads from the homozygous null mice were detached from tails when cultured
• homozygous males and wild-type females did not result in any successful pregnancies, however vaginal plugs were observed in the paired wild-type females
• body mass, the weights of testes and seminal vesicles, the serum testosterone level and polyamine contents are normal
• tailless sperm heads showed no response to the ionophore and acrosome reaction did not take place; however, heads were capable of fertilizing eggs via intracytoplasmic sperm injection

cellular
• Separation of the sperm head and tail was observed in spermatozoa in the cauda epididymis
• the capitulum and striated columns were not apparent in the cytoplasm of the separated head
• almost all of the sperm heads from the homozygous null mice were detached from tails when cultured





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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory