Phenotypes associated with this allele

• Allele Symbol: Tlcd3b^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4462642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tlcd3b^tm1a(EUCOMM)Hmgu/Tlcd3b^+	C57BL/6N-A^tm1Brd Tlcd3b^tm1a(EUCOMM)Hmgu/Ics	MGI:8209537

Genotype
MGI:8209537

ht1

• Allelic Composition: Tlcd3b^{tm1a(EUCOMM)Hmgu}/Tlcd3b⁺
• Genetic Background: C57BL/6N-A^tm1Brd Tlcd3b^{tm1a(EUCOMM)Hmgu}/Ics
• Cell Lines: HEPD0658_2_E07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased brain size ( J:343325 )

♀ • in adult females, the total brain area is reduced by only 3% relative to wild-type females, indicating a very mild effect

decreased retrosplenial granular cortex size ( J:343325 )

♂ • in adult males, the area of the retrosplenial granular cortex is reduced by 19% relative to wild-type males

decreased cingulate cortex size ( J:343325 )

♂ • in adult males, the area of the cingulate cortex is reduced by 11% relative to wild-type males

decreased primary motor cortex size ( J:343325 )

♂ • in adult males, the height of the primary motor cortex is reduced by 9% relative to wild-type males

thin cerebral cortex ( J:343325 )

♂ • adult males show smaller cerebral cortices across several brain parameters relative to wild-type males

decreased piriform cortex size ( J:343325 )

♂ • in adult males, the area of the piriform cortex is decreased by 18% at bregma +0.98 mm and by 20% at bregma -1.34 mm relative to wild-type males