Phenotypes associated with this allele

• Allele Symbol: Chrna1^tm1Klee
• Allele Name: targeted mutation 1, Kuo-Fen Lee
• Allele ID: MGI:4462390
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chrna1^tm1Klee/Chrna1^tm1Klee	involves: 129S4/SvJae * C57BL/6	MGI:4462392
cx2	Agrn^tm4Jrs/Agrn^tm4Jrs Chrna1^tm1Klee/Chrna1^tm1Klee Chrna7^tm1Bay/Chrna7^tm1Bay	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6	MGI:4462396

Genotype
MGI:4462392

hm1

• Allelic Composition: Chrna1^tm1Klee/Chrna1^tm1Klee
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:161300 )

nervous system

abnormal innervation pattern to muscle ( J:161300 )

• the number of nerve branches in muscles is increased compared to in wild-type mice

increased motor neuron number ( J:161300 )

abnormal neuromuscular synapse morphology ( J:161300 )

• synaptic contact length and postsynaptic membrane length in the neuromuscular synapses compared to in wild-type mice

abnormal endplate potential ( J:161300 )

• muscles lack nerve-evoked endplate potential unlike wild-type muscles

abnormal miniature endplate potential ( J:161300 )

• absent

behavior/neurological

carpoptosis ( J:161300 )

• at E15.5

skeleton

kyphosis ( J:161300 )

• at E15.5

Genotype
MGI:4462396

cx2

• Allelic Composition: Agrn^tm4Jrs/Agrn^tm4Jrs; Chrna1^tm1Klee/Chrna1^tm1Klee; Chrna7^tm1Bay/Chrna7^tm1Bay
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

nervous system

failure of neuromuscular synapse presynaptic differentiation ( J:161300 )