Phenotypes associated with this allele

• Allele Symbol: Ago2^tm3.1Ghan
• Allele Name: targeted mutation 3.1, Greggory J Hannon
• Allele ID: MGI:4462371
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ago2^tm3.1Ghan/Ago2^tm3.1Ghan	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA * Swiss Webster	MGI:4462374

Genotype
MGI:4462374

hm1

• Allelic Composition: Ago2^tm3.1Ghan/Ago2^tm3.1Ghan
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * CBA * Swiss Webster

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:161968 )

• mice die within hours of birth

hematopoietic system

abnormal proerythroblast morphology ( J:161968 )

• the number of proerythroblasts is increased 2- to 3-fold in the liver, bone marrow, and spleen compared with wild-type mice

decreased erythrocyte cell number ( J:161968 )

• beginning at E18.5 and worsening after birth

integument

pallor ( J:161968 )

• after birth