All Phenotypes Setdb1<tm2.2Enl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Setdb1^tm2.2Enl
targeted mutation 2.2, En Li
MGI:4462267

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setdb1^tm2.2Enl/Setdb1^tm2.2Enl	involves: 129/Sv * C57BL/6	MGI:4462279
cn2	Setdb1^tm2.1Enl/Setdb1^tm2.2Enl	involves: 129/Sv * C57BL/6	MGI:4462280

Allelic Composition	Setdb1^tm2.2Enl/Setdb1^tm2.2Enl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setdb1^tm2.2Enl mutation (0 available); any Setdb1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:161089 )

• no mice are present at E8.5

Allelic Composition	Setdb1^tm2.1Enl/Setdb1^tm2.2Enl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setdb1^tm2.1Enl mutation (0 available); any Setdb1 mutation (60 available)
Setdb1^tm2.2Enl mutation (0 available); any Setdb1 mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:161089 )

• embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells flatten and appear differentiated unlike untreated cells

• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, expression of pluripotent markers is lost while expression of trophectoderm lineage markers is reduced compared with untreated cells

• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, repressive histone H3K9 methylation is lost unlike in untreated cells

decreased cell proliferation ( J:161089 )

• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells

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