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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Setdb1tm2.1Enl
targeted mutation 2.1, En Li
MGI:4462266
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Setdb1tm2.1Enl/Setdb1tm2.1Enl involves: 129/Sv * C57BL/6 MGI:4462278
cn2
 		Setdb1tm2.1Enl/Setdb1tm2.2Enl involves: 129/Sv * C57BL/6 MGI:4462280


Genotype
MGI:4462278
hm1
Allelic
Composition		 Setdb1tm2.1Enl/Setdb1tm2.1Enl
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setdb1tm2.1Enl mutation (0 available); any Setdb1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:161089 )
• mice are grossly normal and fertile




Genotype
MGI:4462280
cn2
Allelic
Composition		 Setdb1tm2.1Enl/Setdb1tm2.2Enl
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setdb1tm2.1Enl mutation (0 available); any Setdb1 mutation (56 available)
Setdb1tm2.2Enl mutation (0 available); any Setdb1 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:161089 )
• embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells flatten and appear differentiated unlike untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, expression of pluripotent markers is lost while expression of trophectoderm lineage markers is reduced compared with untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, repressive histone H3K9 methylation is lost unlike in untreated cells
decreased cell proliferation ( J:161089 )
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory