Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl2Lp-2J mutation
(1 available);
any
Vangl2 mutation
(34 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vangl2Lp-2J mutation
(1 available);
any
Vangl2 mutation
(34 available)
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mortality/aging
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• some newborns with severe spina bifida die shortly after birth
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• fewer than 50% of offspring from heterozygous intercrosses are heterozygotes
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limbs/digits/tail
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• a short, curled tail is the most common phenotype seen for this mutation with incomplete penetrance
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embryo
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• observed to varying degrees of severity in some, but not all, affected mice and some with mild spina bifida have lived to adulthood and reproduced
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nervous system
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• observed to varying degrees of severity in some, but not all, affected mice and some with mild spina bifida have lived to adulthood and reproduced
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reproductive system
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• some heterozygotes have closed vaginas
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behavior/neurological
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N |
• no abnormal head movement
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hearing/vestibular/ear
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N |
• auditory brainstem response is normal in 2 female and 2 male heterozygotes
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Analysis Tools