All Phenotypes Ccna2<tm1.2Pisc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ccna2^tm1.2Pisc
targeted mutation 1.2, Piotr Sicinski
MGI:4461956

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccna2^tm1.2Pisc/Ccna2^tm1.2Pisc	involves: 129S4/SvJaeSor	MGI:4461992
cn2	Ccna1^tm1Djw/Ccna1^tm1Djw Ccna2^tm1.1Pisc/Ccna2^tm1.2Pisc	involves: 129S4/SvJaeSor * 129S7/SvEvBrd	MGI:4461990

Allelic Composition	Ccna2^tm1.2Pisc/Ccna2^tm1.2Pisc
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna2^tm1.2Pisc mutation (0 available); any Ccna2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:155178 )

• no mice are observed at E7.5

Allelic Composition	Ccna1^tm1Djw/Ccna1^tm1Djw Ccna2^tm1.1Pisc/Ccna2^tm1.2Pisc
Genetic Background	involves: 129S4/SvJaeSor * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1^tm1Djw mutation (0 available); any Ccna1 mutation (28 available)
Ccna2^tm1.1Pisc mutation (0 available); any Ccna2 mutation (15 available)
Ccna2^tm1.2Pisc mutation (0 available); any Ccna2 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell proliferation ( J:155178 )

• cre-transduced embryonic stem cells fail to proliferate unlike similarly treated double heterozygous cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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