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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppargc1btm1.2Rev
targeted mutation 1.2, Ronald M Evans
MGI:4461888
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ppargc1btm1.2Rev/Ppargc1btm1.2Rev
Tg(Tek-cre)1Ywa/0 		involves: 129/Sv * C57BL/6 * C57BL/6J * SJL MGI:4461914


Genotype
MGI:4461914
cn1
Allelic
Composition		 Ppargc1btm1.2Rev/Ppargc1btm1.2Rev
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargc1btm1.2Rev mutation (0 available); any Ppargc1b mutation (59 available)
Tg(Tek-cre)1Ywa mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal osteoclast differentiation ( J:160910 )
• bone marrow cells in vitro stimulated with rosiglitazone exhibit reduced differentiation into osteoclasts compared with similarly treated bone marrow cells from Ppargc1btm1.2Rev homozygotes
decreased bone resorption ( J:160910 )
• mice are resistant to rosiglitazone-induced bone loss unlike Ppargc1btm1.2Rev homozygotes

immune system
abnormal osteoclast differentiation ( J:160910 )
• bone marrow cells in vitro stimulated with rosiglitazone exhibit reduced differentiation into osteoclasts compared with similarly treated bone marrow cells from Ppargc1btm1.2Rev homozygotes

hematopoietic system
abnormal osteoclast differentiation ( J:160910 )
• bone marrow cells in vitro stimulated with rosiglitazone exhibit reduced differentiation into osteoclasts compared with similarly treated bone marrow cells from Ppargc1btm1.2Rev homozygotes

cellular
abnormal osteoclast differentiation ( J:160910 )
• bone marrow cells in vitro stimulated with rosiglitazone exhibit reduced differentiation into osteoclasts compared with similarly treated bone marrow cells from Ppargc1btm1.2Rev homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory