Phenotypes associated with this allele

• Allele Symbol: Carf^tm1.1Aew
• Allele Name: targeted mutation 1.1, Anne West
• Allele ID: MGI:4461230
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Carf^tm1.1Aew/Carf^tm1.1Aew	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4461231

Genotype
MGI:4461231

hm1

• Allelic Composition: Carf^tm1.1Aew/Carf^tm1.1Aew
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:160811 )

• extinguishes conditioned fear more slowly than their wild-type littermates

abnormal object recognition memory ( J:160811 )

• impairments during the remote memory phase of testing suggestive of defects in cortical-regulated remote memory

impaired short-term object recognition memory ( J:160811 )

• mice have less of a preference for a novel object during the first three minutes but more of a preference during the final three minutes than wild-type mice

abnormal spatial reference memory ( J:160811 )

• enhanced ability to find a new platform location on the first day of reversal training in the water maze