Phenotypes associated with this allele

• Allele Symbol: Apc^tm1.1Tyj
• Allele Name: targeted mutation 1.1, Tyler Jacks
• Allele ID: MGI:4461178
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Apc^tm1.1Tyj/Apc^+	involves: 129S4/SvJaeSor * C57BL/6	MGI:4461184

Genotype
MGI:4461184

ht1

• Allelic Composition: Apc^tm1.1Tyj/Apc⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:160399 )

• lifespan is decreased compared to mice heterozygous for Apc^Min

neoplasm

increased intestinal adenoma incidence ( J:160399 )

• at 3 months of age small intestinal tumor number is increased compared to mice heterozygous for Apc^Min

• increase in tumor numbers is more pronounced in females

increased colon adenoma incidence ( J:160399 )

• at 3 months of age colonic tumor number is increased compared to mice heterozygous for Apc^Min

• increase in tumor numbers is more pronounced in females

increased tumor growth/size ( J:160399 )

• in females at 3 months of age intestinal tumors are about twice the volume of tumors in female mice heterozygous for Apc^Min

hematopoietic system

anemia ( J:160399 )

• in aged mice

digestive/alimentary system

increased intestinal adenoma incidence ( J:160399 )

• at 3 months of age small intestinal tumor number is increased compared to mice heterozygous for Apc^Min

• increase in tumor numbers is more pronounced in females

increased colon adenoma incidence ( J:160399 )

• at 3 months of age colonic tumor number is increased compared to mice heterozygous for Apc^Min

• increase in tumor numbers is more pronounced in females