All Phenotypes Tor1aip1<Gt(GST004691)Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tor1aip1^{Gt(GST004691)Lex}
gene trap GST004691
MGI:4460952

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tor1aip1^{Gt(GST004691)Lex}/Tor1aip1^{Gt(GST004691)Lex}	Not Specified	MGI:4460957
cx2	Tor1a^tm1Wtd/Tor1a⁺ Tor1aip1^{Gt(GST004691)Lex}/Tor1aip1⁺	involves: 129S1/Sv	MGI:4460959

Allelic Composition	Tor1aip1^{Gt(GST004691)Lex}/Tor1aip1^{Gt(GST004691)Lex}
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tor1aip1^{Gt(GST004691)Lex} mutation (0 available); any Tor1aip1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:160544 )

• mice die between E18 and P0

cellular

abnormal cell nucleus morphology ( J:160544 )

• nuclear membranes from neural tissue and cultured neurons are abnormal with perinuclear blebs compared to in wild-type cells

• nuclear membranes from nonneural tissues exhibit blebs unlike in wild-type cells

Allelic Composition	Tor1a^tm1Wtd/Tor1a⁺ Tor1aip1^{Gt(GST004691)Lex}/Tor1aip1⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tor1aip1^{Gt(GST004691)Lex} mutation (0 available); any Tor1aip1 mutation (41 available)
Tor1a^tm1Wtd mutation (1 available); any Tor1a mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell nucleus morphology ( J:160544 )

• nuclear blebs are observed unlike in single heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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