All Phenotypes Gimap1<tm1.1Gwb> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gimap1^tm1.1Gwb
targeted mutation 1.1, Geoffrey W Butcher
MGI:4459837

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gimap1^tm1.1Gwb/Gimap1^tm1.1Gwb Tg(CD2-icre)4Kio/0	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:4459839

Allelic Composition	Gimap1^tm1.1Gwb/Gimap1^tm1.1Gwb Tg(CD2-icre)4Kio/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gimap1^tm1.1Gwb mutation (0 available); any Gimap1 mutation (8 available)
Tg(CD2-icre)4Kio mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased lymphocyte cell number ( J:160782 )

• the overall spleenic cellularity is reduced by approximately 40%

• the lymph node cellualrity is severely reduced

decreased B cell number ( J:160782 )

• in lymph nodes

decreased transitional stage T2 B cell number ( J:160782 )

decreased B-1a cell number ( J:160782 )

• in peritoneum

decreased B-1b cell number ( J:160782 )

• in peritoneum

decreased B-2 B cell number ( J:160782 )

• in peritoneum

decreased follicular B cell number ( J:160782 )

decreased marginal zone B cell number ( J:160782 )

decreased T cell number ( J:160782 )

• in peritoneum and blood

decreased thymocyte number ( J:160782 )

decreased CD4-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD4 single positive subset in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD8 single positive subset in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:160782 )

• decreased thymocyte survival in culture

abnormal CD8-positive, alpha-beta T cell physiology ( J:160782 )

• a trend towards decreased thymocyte survival in culture

immune system

decreased lymphocyte cell number ( J:160782 )

• the overall spleenic cellularity is reduced by approximately 40%

• the lymph node cellualrity is severely reduced

decreased B cell number ( J:160782 )

• in lymph nodes

decreased transitional stage T2 B cell number ( J:160782 )

decreased B-1a cell number ( J:160782 )

• in peritoneum

decreased B-1b cell number ( J:160782 )

• in peritoneum

decreased B-2 B cell number ( J:160782 )

• in peritoneum

decreased follicular B cell number ( J:160782 )

decreased marginal zone B cell number ( J:160782 )

decreased T cell number ( J:160782 )

• in peritoneum and blood

decreased thymocyte number ( J:160782 )

decreased CD4-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD4 single positive subset in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD8 single positive subset in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:160782 )

• decreased thymocyte survival in culture

abnormal CD8-positive, alpha-beta T cell physiology ( J:160782 )

• a trend towards decreased thymocyte survival in culture

endocrine/exocrine glands

decreased thymocyte number ( J:160782 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23