Phenotypes associated with this allele

• Allele Symbol: Timd4^tm1Kuch
• Allele Name: targeted mutation 1, Vijay Kuchroo
• Allele ID: MGI:4459812
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timd4^tm1Kuch/Timd4^tm1Kuch	C57BL/6-Timd4^tm1Kuch	MGI:4459813
hm2	Timd4^tm1Kuch/Timd4^tm1Kuch	involves: C57BL/6	MGI:6287981

Genotype
MGI:4459813

hm1

• Allelic Composition: Timd4^tm1Kuch/Timd4^tm1Kuch
• Genetic Background: C57BL/6-Timd4^tm1Kuch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased splenocyte proliferation ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

abnormal B cell physiology ( J:160747 )

• B-1 cells are hyper-proliferative

• B-1 cells do not efficiently uptake apoptotic bodies

increased IgA level ( J:160747 )

increased IgG2a level ( J:160747 )

increased IgG2b level ( J:160747 )

abnormal macrophage physiology ( J:160747 )

• peritoneal macrophages do not efficiently uptake apoptotic bodies

increased interferon-gamma secretion ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

increased interleukin-17 secretion ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

increased anti-double stranded DNA antibody level ( J:160747 )

• significantly higher titers of antibody against dsDNA in females and a trend toward increased levels in males

hematopoietic system

increased splenocyte proliferation ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

abnormal B cell physiology ( J:160747 )

• B-1 cells are hyper-proliferative

• B-1 cells do not efficiently uptake apoptotic bodies

increased IgA level ( J:160747 )

increased IgG2a level ( J:160747 )

increased IgG2b level ( J:160747 )

abnormal macrophage physiology ( J:160747 )

• peritoneal macrophages do not efficiently uptake apoptotic bodies

cellular

increased splenocyte proliferation ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

Genotype
MGI:6287981

hm2

• Allelic Composition: Timd4^tm1Kuch/Timd4^tm1Kuch
• Genetic Background: involves: C57BL/6

homeostasis/metabolism

increased circulating creatinine level ( J:235399 )

abnormal circulating chemokine level ( J:235399 )

• levels of CXCL1, CCL4 and CCL2 are increased in 52-week old mice

increased circulating interleukin-1 beta level ( J:235399 )

• in 52-week old mice

decreased circulating interleukin-10 level ( J:235399 )

• in 52-week old mice

increased circulating interleukin-12b level ( J:235399 )

• in 52-week old mice

increased circulating interleukin-6 level ( J:235399 )

• in 52-week old mice

immune system

abnormal circulating chemokine level ( J:235399 )

• levels of CXCL1, CCL4 and CCL2 are increased in 52-week old mice

increased circulating interleukin-1 beta level ( J:235399 )

• in 52-week old mice

decreased circulating interleukin-10 level ( J:235399 )

• in 52-week old mice

increased circulating interleukin-12b level ( J:235399 )

• in 52-week old mice

increased circulating interleukin-6 level ( J:235399 )

• in 52-week old mice

increased susceptibility to systemic lupus erythematosus ( J:235399 )

• mice display lupus-like disease

increased anti-double stranded DNA antibody level ( J:235399 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:235399