Phenotypes associated with this allele

• Allele Symbol: Timd4^tm1Kuch
• Allele Name: targeted mutation 1, Vijay Kuchroo
• Allele ID: MGI:4459812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timd4^tm1Kuch/Timd4^tm1Kuch	C57BL/6-Timd4^tm1Kuch	MGI:4459813

Genotype
MGI:4459813

hm1

• Allelic Composition: Timd4^tm1Kuch/Timd4^tm1Kuch
• Genetic Background: C57BL/6-Timd4^tm1Kuch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased splenocyte proliferation ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

abnormal B cell physiology ( J:160747 )

• B-1 cells are hyper-proliferative

• B-1 cells do not efficiently uptake apoptotic bodies

increased IgA level ( J:160747 )

increased IgG2a level ( J:160747 )

increased IgG2b level ( J:160747 )

abnormal macrophage physiology ( J:160747 )

• peritoneal macrophages do not efficiently uptake apoptotic bodies

increased interferon-gamma secretion ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

increased interleukin-17 secretion ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

increased anti-double stranded DNA antibody level ( J:160747 )

• significantly higher titers of antibody against dsDNA in females and a trend toward increased levels in males

hematopoietic system

increased splenocyte proliferation ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro

abnormal B cell physiology ( J:160747 )

• B-1 cells are hyper-proliferative

• B-1 cells do not efficiently uptake apoptotic bodies

increased IgA level ( J:160747 )

increased IgG2a level ( J:160747 )

increased IgG2b level ( J:160747 )

abnormal macrophage physiology ( J:160747 )

• peritoneal macrophages do not efficiently uptake apoptotic bodies

cellular

increased splenocyte proliferation ( J:160747 )

• by splenocytes from MOG peptide immunized mice when reactivated in vitro