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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lrp1btm1Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:4459742
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lrp1btm1Wtsi/Lrp1btm1Wtsi involves: 129S7/SvEvBrd * C57BL/6J MGI:4459743
ht2
 		Lrp1btm1Wtsi/Lrp1btm2Wtsi involves: 129S7/SvEvBrd * C57BL/6J MGI:4459809


Genotype
MGI:4459743
hm1
Allelic
Composition		 Lrp1btm1Wtsi/Lrp1btm1Wtsi
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1btm1Wtsi mutation (0 available); any Lrp1b mutation (303 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:160170 )
• no mice were observed at weaning




Genotype
MGI:4459809
ht2
Allelic
Composition		 Lrp1btm1Wtsi/Lrp1btm2Wtsi
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp1btm1Wtsi mutation (0 available); any Lrp1b mutation (303 available)
Lrp1btm2Wtsi mutation (0 available); any Lrp1b mutation (303 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:160170 )
N
• flushed blastocysts at E3.5 show normal morphology with a time-and size-appropriate expansion of the inner cell mass and outgrowth of trophoblast structures




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory