Phenotypes associated with this allele

• Allele Symbol: Il17rb^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:4459522
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il17rb^tm1Lex/Il17rb^tm1Lex	C.129-Il17rb^tm1Lex	MGI:4459523

Genotype
MGI:4459523

hm1

• Allelic Composition: Il17rb^tm1Lex/Il17rb^tm1Lex
• Genetic Background: C.129-Il17rb^tm1Lex

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal osteoclast differentiation ( J:159874 )

• IL17A or IL17F induced osteoclast differentiation is completely abolished

abnormal chemokine secretion ( J:159874 )

• KC/CXCL1 and G-CSF are not induced by lung fibroblasts or MEFs in response to IL17A or IL17F application

decreased interleukin-5 secretion ( J:159874 )

• IL5 induction is abolished in splenocytes

decreased interleukin-6 secretion ( J:159874 )

• by lung fibroblasts or MEFs in response to IL17A or IL7F application

hematopoietic system

abnormal osteoclast differentiation ( J:159874 )

• IL17A or IL17F induced osteoclast differentiation is completely abolished

skeleton

abnormal osteoclast differentiation ( J:159874 )

• IL17A or IL17F induced osteoclast differentiation is completely abolished

cellular

abnormal osteoclast differentiation ( J:159874 )

• IL17A or IL17F induced osteoclast differentiation is completely abolished