Phenotypes associated with this allele

• Allele Symbol: Tpbg^tm1Plst
• Allele Name: targeted mutation 1, Peter L Stern
• Allele ID: MGI:4459319
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tpbg^tm1Plst/Tpbg^tm1Plst	involves: C57BL/6	MGI:4459403
hm2	Tpbg^tm1Plst/Tpbg^tm1Plst	Not Specified	MGI:4459402

Genotype
MGI:4459403

hm1

• Allelic Composition: Tpbg^tm1Plst/Tpbg^tm1Plst
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:160174 )

• median age of death is 49 days unlike wild-type mice

nervous system

hydrocephaly ( J:160174 )

• in 13% of mice

cellular

abnormal cell migration ( J:160174 )

• differentiated embryonic stem cells fail to respond to CXCL12 unlike similarly treated wild-type mice

Genotype
MGI:4459402

hm2

• Allelic Composition: Tpbg^tm1Plst/Tpbg^tm1Plst
• Genetic Background: Not Specified

cellular

abnormal cell differentiation ( J:128085 )

• embryonic stem cells treated with DECMA-1 antibodies fail to exhibit a mesenchyme phenotype unlike similarly treated wild-type cells

abnormal cell migration ( J:128085 )

• in the absence of LIF, embryonic stem cells do not exhibit as much of an increase in migration as similarly treated wild-type cells and lack a motile phenotype