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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ripply1tm1.1Sjt
targeted mutation 1.1, Shinji Takada
MGI:4459309
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ripply1tm1.1Sjt/Ripply1tm1.1Sjt involves: 129S1/Sv * FVB/N MGI:4459312
cx2
 		Ripply1tm1.1Sjt/Ripply1tm1.1Sjt
Ripply2tm1.1Ysa/Ripply2tm1.1Ysa 		involves: 129S1/Sv * C57BL/6 * CBA * FVB/N MGI:4459313
cx3
 		Ripply1tm1.1Sjt/Y
Ripply2tm1.1Ysa/Ripply2tm1.1Ysa 		involves: 129S1/Sv * C57BL/6 * CBA * FVB/N MGI:4459314
ot4
 		Ripply1tm1.1Sjt/Y involves: 129S1/Sv * FVB/N MGI:4459311


Genotype
MGI:4459312
hm1
Allelic
Composition		 Ripply1tm1.1Sjt/Ripply1tm1.1Sjt
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1tm1.1Sjt mutation (0 available); any Ripply1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal cervical vertebrae morphology ( J:161418 )
• some mice exhibit an extension of the seventh cervical vertebra that fuses to the first rib unlike in wild-type mice




Genotype
MGI:4459313
cx2
Allelic
Composition		 Ripply1tm1.1Sjt/Ripply1tm1.1Sjt
Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1tm1.1Sjt mutation (0 available); any Ripply1 mutation (11 available)
Ripply2tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebrae morphology ( J:161418 )
• mice exhibit rostralization of vertebrae compared with wild-type mice that is enhanced compared to in Ripply2tm1.1Ysa homozygotes
absent vertebral pedicles ( J:161418 )
• with fusion of the lamina in the vertebrae

embryo
abnormal rostral-caudal patterning of the somites ( J:161418 )
• marker expression reveals rostralization of somites compared to in wild-type mice




Genotype
MGI:4459314
cx3
Allelic
Composition		 Ripply1tm1.1Sjt/Y
Ripply2tm1.1Ysa/Ripply2tm1.1Ysa
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1tm1.1Sjt mutation (0 available); any Ripply1 mutation (11 available)
Ripply2tm1.1Ysa mutation (1 available); any Ripply2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal vertebrae morphology ( J:161418 )
• mice exhibit rostralization of vertebrae compared with wild-type mice that is enhanced compared to in Ripply2tm1.1Ysa homozygotes
absent vertebral pedicles ( J:161418 )
• with fusion of the lamina in the vertebrae

embryo
abnormal rostral-caudal patterning of the somites ( J:161418 )
• marker expression reveals rostralization of somites compared to in wild-type mice




Genotype
MGI:4459311
ot4
Allelic
Composition		 Ripply1tm1.1Sjt/Y
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ripply1tm1.1Sjt mutation (0 available); any Ripply1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal cervical vertebrae morphology ( J:161418 )
• some mice exhibit an extension of the seventh cervical vertebra that fuses to the first rib unlike in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory