Phenotypes associated with this allele

• Allele Symbol: Adamts12^tm1Agno
• Allele Name: targeted mutation 1, Agnes Noel
• Allele ID: MGI:4457760
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts12^tm1Agno/Adamts12^tm1Agno	Not Specified	MGI:4457863

Genotype
MGI:4457863

hm1

• Allelic Composition: Adamts12^tm1Agno/Adamts12^tm1Agno
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

abnormal tumor vascularization ( J:160778 )

• transplanted malignant PDVA tumor cells exhibit increased vascularization compared to in similarly treated wild-type mice

• the area of blood vessels that intermingles with transplanted tumor cells is twice as high as in similarly treated wild-type mice

increased tumor growth/size ( J:160778 )

• transplanted malignant PDVA tumor cells exhibit increased invasion and migration compared to in similarly treated wild-type mice

cardiovascular system

abnormal tumor vascularization ( J:160778 )

• transplanted malignant PDVA tumor cells exhibit increased vascularization compared to in similarly treated wild-type mice

• the area of blood vessels that intermingles with transplanted tumor cells is twice as high as in similarly treated wild-type mice

increased angiogenesis ( J:160778 )

• in vivo and ex vivo angiogenesis is increased compared with wild-type mice

• aortic rings exhibit increased capillary outgrowth compared with wild-type rings