All Phenotypes Tmprss6<tm1Dgen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tmprss6^tm1Dgen
targeted mutation 1, Deltagene
MGI:4457116

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	B6.129P2-Tmprss6^tm1Dgen/Crl	MGI:4457129
hm2	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457133
ht3	Tmprss6^tm1Dgen/Tmprss6⁺	B6.129P2-Tmprss6^tm1Dgen/Crl	MGI:4457132
ht4	Tmprss6^tm1Dgen/Tmprss6⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457138
ht5	Tmprss6^hem8/Tmprss6^tm1Dgen	involves: C57BL/6 * C57BL/6J	MGI:5829240
cx6	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457137
cx7	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457135
cx8	Hjv^tm1Nca/Hjv⁺ Tmprss6^tm1Dgen/Tmprss6^tm1Dgen	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:4457134

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	B6.129P2-Tmprss6^tm1Dgen/Crl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:160248 )

• fewer than expected mice are produced on a congenic C57BL/6 background unlike on a mixed background

hematopoietic system

increased spleen weight ( J:160248 )

• mice exhibit a trend toward increased spleen weight compared with wild-type mice

extramedullary hematopoiesis ( J:160248 )

• in the spleen

microcytic anemia ( J:160248 )

• by 8 weeks

abnormal erythrocyte morphology ( J:160248 )

decreased erythrocyte cell number ( J:160248 )

decreased hematocrit ( J:160248 )

decreased hemoglobin content ( J:160248 )

decreased mean corpuscular hemoglobin ( J:237155 )

• at 2 months of age

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 , J:237155 )

• at 2 months of age (J:237155)

increased red blood cell distribution width ( J:160248 )

reticulocytosis ( J:237155 )

• at 2 months of age

decreased spleen iron level ( J:160248 )

• mice exhibit a trend toward decreased spleen iron levels compared with wild-type mice

homeostasis/metabolism

increased circulating unsaturated transferrin level ( J:237155 )

• decreased transferrin saturations at 2 months of age

abnormal iron homeostasis ( J:237155 )

• increased liver hepcidin RNA levels at 2 months of age

• decreased liver Bmp6 and Tmprss6 RNA levels

• however, liver Id1 RNA levels are relatively unchanged

decreased spleen iron level ( J:160248 )

• mice exhibit a trend toward decreased spleen iron levels compared with wild-type mice

decreased circulating iron level ( J:160248 , J:237155 )

• by 8 weeks (J:160248)

• decreased serum iron levels at 2 months of age (J:237155)

• however, spleen iron levels are normal (J:237155)

decreased liver iron level ( J:160248 , J:237155 )

• at 2 months of age (J:237155)

liver/biliary system

decreased liver iron level ( J:160248 , J:237155 )

• at 2 months of age (J:237155)

growth/size/body

decreased body size ( J:160248 )

increased spleen weight ( J:160248 )

• mice exhibit a trend toward increased spleen weight compared with wild-type mice

immune system

increased spleen weight ( J:160248 )

• mice exhibit a trend toward increased spleen weight compared with wild-type mice

decreased spleen iron level ( J:160248 )

• mice exhibit a trend toward decreased spleen iron levels compared with wild-type mice

integument

alopecia ( J:160248 , J:237155 )

• mice develop truncal alopecia before weaning unlike wild-type mice (J:160248)

• body hair loss sparing the face (J:237155)

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:160248 )

N	• Background Sensitivity: mice on a mixed background are represented in Mendelian ratio unlike mice on a congenic C57BL/6 background

endocrine/exocrine glands

decreased pancreas iron level ( J:160248 )

• at 8 weeks

hematopoietic system

microcytic anemia ( J:160248 )

• at 8 weeks

decreased erythrocyte cell number ( J:160248 )

decreased hematocrit ( J:160248 )

decreased hemoglobin content ( J:160248 )

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

increased red blood cell distribution width ( J:160248 )

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit decreased liver, heart, pancreas, and skeletal muscle iron levels compared with wild-type mice

• however, spleen iron levels are normal

decreased heart iron level ( J:160248 )

• at 8 weeks

decreased pancreas iron level ( J:160248 )

• at 8 weeks

decreased liver iron level ( J:160248 )

• at 8 weeks

liver/biliary system

decreased liver iron level ( J:160248 )

• at 8 weeks

cardiovascular system

decreased heart iron level ( J:160248 )

• at 8 weeks

integument

alopecia ( J:160248 )

• mice develop truncal alopecia before weaning unlike wild-type mice

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6⁺
Genetic Background	B6.129P2-Tmprss6^tm1Dgen/Crl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

decreased spleen iron level ( J:160248 )

• slightly in pregnant mice compared with pregnant wild-type mice

homeostasis/metabolism

decreased spleen iron level ( J:160248 )

• slightly in pregnant mice compared with pregnant wild-type mice

decreased circulating iron level ( J:160248 )

• mice exhibit a trend toward decreased serum iron levels compared with wild-type mice

decreased liver iron level ( J:160248 )

• mice exhibit decreased hepatic iron levels compared with wild-type mice

liver/biliary system

decreased liver iron level ( J:160248 )

• mice exhibit decreased hepatic iron levels compared with wild-type mice

immune system

decreased spleen iron level ( J:160248 )

• slightly in pregnant mice compared with pregnant wild-type mice

cellular

maternal effect ( J:160248 )

• pup from heterozygous dams exhibit reduced hepatic iron levels compared with pups from wild-type mice

• however, pups from heterozygous dams exhibit normal hematologic and serum parameters

Allelic Composition	Tmprss6^tm1Dgen/Tmprss6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

Allelic Composition	Tmprss6^hem8/Tmprss6^tm1Dgen
Genetic Background	involves: C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmprss6^hem8 mutation (0 available); any Tmprss6 mutation (46 available)
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased mean corpuscular hemoglobin ( J:237155 )

• at 2 months of age

decreased mean corpuscular volume ( J:237155 )

• at 2 months of age

reticulocytosis ( J:237155 )

• increased reticulocyte counts at 2 months of age

homeostasis/metabolism

increased circulating unsaturated transferrin level ( J:237155 )

• decreased transferrin saturations at 2 months of age

abnormal iron homeostasis ( J:237155 )

• increased liver hepcidin RNA levels at 2 months of age

decreased circulating iron level ( J:237155 )

• decreased serum iron levels at 2 months of age

decreased liver iron level ( J:237155 )

• at 2 months of age

liver/biliary system

decreased liver iron level ( J:237155 )

• at 2 months of age

Allelic Composition	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hjv^tm1Nca mutation (1 available); any Hjv mutation (17 available)
Tmprss6^tm1Dgen mutation (0 available); any Tmprss6 mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit increased liver, heart, pancreas, and muscle iron levels compared with wild-type mice

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

hematopoietic system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

liver/biliary system

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

abnormal hepatocyte morphology ( J:160248 )

• hepatocytes exhibit increased iron accumulation compared with wild-type cells

immune system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

integument

integument phenotype ( J:160248 )

N	• mice retain full body hair

Allelic Composition	Hjv^tm1Nca/Hjv^tm1Nca Tmprss6^tm1Dgen/Tmprss6⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit increased liver, heart, pancreas, and muscle iron levels compared with wild-type mice

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

hematopoietic system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

liver/biliary system

increased liver iron level ( J:160248 )

• at 8 weeks, specifically in hepatocytes

abnormal hepatocyte morphology ( J:160248 )

• hepatocytes exhibit increased iron accumulation compared with wild-type cells

immune system

abnormal macrophage morphology ( J:160248 )

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

decreased spleen iron level ( J:160248 )

• spleen iron levels are decreased compared to in wild-type mice

• splenic macrophages exhibit decreased iron levels compared with wild-type cells

Allelic Composition	Hjv^tm1Nca/Hjv⁺ Tmprss6^tm1Dgen/Tmprss6^tm1Dgen
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased pancreas iron level ( J:160248 )

• at 8 weeks

hematopoietic system

microcytic anemia ( J:160248 )

• at 8 weeks

decreased erythrocyte cell number ( J:160248 )

decreased hematocrit ( J:160248 )

decreased hemoglobin content ( J:160248 )

decreased mean corpuscular hemoglobin concentration ( J:160248 )

decreased mean corpuscular volume ( J:160248 )

increased red blood cell distribution width ( J:160248 )

homeostasis/metabolism

abnormal iron level ( J:160248 )

• at 8 weeks, mice exhibit decreased liver, heart, pancreas, and skeletal muscle iron levels compared with wild-type mice

• however, spleen iron levels are normal

decreased heart iron level ( J:160248 )

• decreased at 8 weeks

decreased pancreas iron level ( J:160248 )

• at 8 weeks

decreased liver iron level ( J:160248 )

• at 8 weeks

liver/biliary system

decreased liver iron level ( J:160248 )

• at 8 weeks

cardiovascular system

decreased heart iron level ( J:160248 )

• decreased at 8 weeks

integument

sparse hair ( J:160248 )

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