Analysis Tools
mortality/aging
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• mice begin to die before E10.5 and are dead by E11.5
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cardiovascular system
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• mice exhibit reduced vascular complexity particularly in the head capillary plexus and branchial arches compared with wild-type mice
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• mice exhibit reduced vascular complexity particularly in the head capillary plexus and branchial arches compared with wild-type mice
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• mice exhibit reduced number of myocardial cells compared with wild-type mice without an increase in apoptosis in the heart
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• increased in thickness at E10.5
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• the septum of the atrium of the E10.5 mutant mice has not developed
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• thin
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• at E10.5, mice exhibit dilated heart unlike wild-type mice
• however, heart development between E8.5 and E9.5 and heart looping are normal
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embryo
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• branchial arches remain at E11.5 unlike in wild-type mice
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• at E9.5
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nervous system
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• at E9.5, mice exhibit apoptosis in the neural tube unlike in wild-type mice
• at E10.5, apoptosis in the neural tube is further increased unlike in wild-type mice
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• at E10.5, forebrains are smaller than in wild-type mice
• at E11.5, the front brain is undifferentiated unlike in wild-type mice
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growth/size/body
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• at E9.5
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homeostasis/metabolism
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• mice exhibit increased squalene and lanosterol and decreased cholestenol, lathosterol, and desmosterol levels compared with wild-type mice
• however, total cholesterol levels are normal
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craniofacial
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• branchial arches remain at E11.5 unlike in wild-type mice
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muscle
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• mice exhibit reduced number of myocardial cells compared with wild-type mice without an increase in apoptosis in the heart
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• increased in thickness at E10.5
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cellular
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• at E9.5, mice exhibit apoptosis in the neural tube unlike in wild-type mice
• at E10.5, apoptosis in the neural tube is further increased unlike in wild-type mice
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