Analysis Tools
mortality/aging
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• mice do not survive embryogenesis
• some mice die prior to E9.5
• no mice are recovered at E11.5 and E12.5
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embryo
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• mice fail to turn by E9.5
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• at E10.5, the caudal end of the embryo is reduced in size and consists of a small, malformed tail bud devoid of tissue unlike in wild-type mice
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• at E8.5
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• at E9.5
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• at E8.5, fewer than expected somites have formed when compared with wild-type mice
• at E9.5, 0 to 10 somites have formed compared with 20-22 in wild-type mice
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• small and irregularly shaped at E9.5
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• at E9.5
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• bulbous at E9.5
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• at E10.5
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• at E8.5 likely due to overall developmental delay
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cardiovascular system
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• 54% of mice exhibit irregular heart looping when compared with wild-type mice
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• in 23% of mice
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• in 10% of mice at E.9.5
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limbs/digits/tail
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• small and irregularly shaped at E9.5
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• at E9.5
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nervous system
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• at E9.5
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growth/size/body
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• at E8.5
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