Phenotypes associated with this allele

• Allele Symbol: Sox10^{tm6(Sox100B)Weg}
• Allele Name: targeted mutation 6, Michael Wegner
• Allele ID: MGI:4456384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox10^tm6(Sox100B)Weg/Sox10^tm6(Sox100B)Weg	involves: 129P2/OlaHsd * C3H	MGI:4456389

Genotype
MGI:4456389

hm1

• Allelic Composition: Sox10^{tm6(Sox100B)Weg}/Sox10^{tm6(Sox100B)Weg}
• Genetic Background: involves: 129P2/OlaHsd * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:160023 )

• mice die immediately after birth

nervous system

nervous system phenotype ( J:160023 )

N • Schwann cell and oligodendrocyte development is normal

abnormal melanoblast morphology ( J:160023 )

• at E12.5, fewer melanoblasts are found than in wild-type mice

abnormal enteric nervous system morphology ( J:160023 )

• within the duodenum, localization of enteric nervous system cell bodies and overall organization of the plexus is slightly different than in wild-type mice

• within the jejunum, the enteric nervous system is composed of few cells and the plexus is not formed unlike in wild-type mice

• enteric nervous system cells are completely missing from the caecal level and beyond unlike in wild-type mice

abnormal sympathetic ganglion morphology ( J:160023 )

• as determined by TH staining, the size of the sympathetic ganglia is reduced at E12.5 and E18.5 compared to in wild-type mice

• TH+ cells occupy a reduced area of the adrenal medulla compared to in wild-type mice

abnormal sympathetic neuron morphology ( J:160023 )

• at E12.5 and E18.5, fewer Phox2b+ cells are detected compared to in wild-type mice

decreased neuron number ( J:160023 )

• at E12.5 and E18.5, fewer neurons are found in the dorsal root ganglia compared to in wild-type mice

abnormal dorsal root ganglion morphology ( J:160023 )

• at E12.5, the number of glial cells in the dorsal root ganglia is slightly decreased compared to in wild-type mice

• at E12.5 and E18.5, fewer neurons are found in the dorsal root ganglia compared to in wild-type mice

• however, the number of glial cells at E18.5 is normal

dorsal root ganglion hypoplasia ( J:160023 )

endocrine/exocrine glands

abnormal adrenal medulla morphology ( J:160023 )

• TH+ cells occupy a reduced area of the adrenal medulla compared to in wild-type mice

embryo

abnormal melanoblast morphology ( J:160023 )

• at E12.5, fewer melanoblasts are found than in wild-type mice