Analysis Tools
mortality/aging
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• no mice are present at E7.5
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Allele Symbol Allele Name Allele ID |
Gmnntm1.2Kio targeted mutation 1.2, Dimitris Kioussis MGI:4456373 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no mice are present at E7.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells
• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells
• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells
• however, T cells exhibit normal apoptosis and entry into S phase
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• moderate
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• moderate
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• moderate
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• mice exhibit a reduction of CD4+, CD4+CD62L-, and CD4+CD44hi cells compared with control mice
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• mice exhibit a reduction of CD8+ and CD8+CD62L- cells compared with control mice
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• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells
• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells
• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells
• however, T cells exhibit normal apoptosis and entry into S phase
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• moderate
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• moderate
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• moderate
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• mice exhibit a reduction of CD4+, CD4+CD62L-, and CD4+CD44hi cells compared with control mice
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• mice exhibit a reduction of CD8+ and CD8+CD62L- cells compared with control mice
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• moderate
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• moderate
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• in response to mitogenic stimulation (anti-CD3 plus anti-CD28, or PDBU and ionomycin or Con A), T cells exhibit decreased proliferation compared with similarly treated control cells
• anti-CD3 and anti-CD28-treated T cells exhibit an increase in percentage of cells at the G2/M phase and accumulate in G2 phase compared with similarly treated control cells
• T cells fail to exhibit spontaneous proliferation in a T cell depleted mouse with reduced CD8 T cells compared with control cells
• however, T cells exhibit normal apoptosis and entry into S phase
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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