Phenotypes associated with this allele

• Allele Symbol: Irf4^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:4456226
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irf4^m1Btlr/Irf4^m1Btlr	C57BL/6J-Irf4^m1Btlr	MGI:4456232
hm2	Irf4^m1Btlr/Irf4^m1Btlr	involves: C57BL/6J	MGI:5429188

Genotype
MGI:4456232

hm1

• Allelic Composition: Irf4^m1Btlr/Irf4^m1Btlr
• Genetic Background: C57BL/6J-Irf4^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell activation ( J:160882 )

• no detectable T cell-independent immunoglobulin M (IgM) response to haptenated Ficoll (TNP-Ficoll) stimulation

• no detectable T cell-dependent immunoglobulin G (IgG) response to stimulation by model antigens encoded by a recombinant suicide vector based on the Semliki Forest Virus (rSFV)

• despite the failure of B lymphocyte response to both T cell-dependent and -independent stimulation, fluorescence activated cell sorting (FACS) analysis demonstrated normal frequencies of transitional and mature follicular B cells

decreased IgG level ( J:160882 )

• no detectable T cell-dependent immunoglobulin G (IgG) response to stimulation by model antigens encoded by a recombinant suicide vector based on the Semliki Forest Virus (rSFV)

• despite the failure of B lymphocyte response to T cell-dependent antigen stimulation, FACS analysis of blood from the index mouse demonstrated normal frequencies of CD4⁺ T cells

decreased IgM level ( J:160882 )

• no detectable T cell-independent immunoglobulin M (IgM) response to haptenated Ficoll (TNP-Ficoll) stimulation

immune system

abnormal B cell activation ( J:160882 )

• no detectable T cell-independent immunoglobulin M (IgM) response to haptenated Ficoll (TNP-Ficoll) stimulation

• no detectable T cell-dependent immunoglobulin G (IgG) response to stimulation by model antigens encoded by a recombinant suicide vector based on the Semliki Forest Virus (rSFV)

• despite the failure of B lymphocyte response to both T cell-dependent and -independent stimulation, fluorescence activated cell sorting (FACS) analysis demonstrated normal frequencies of transitional and mature follicular B cells

decreased IgG level ( J:160882 )

• no detectable T cell-dependent immunoglobulin G (IgG) response to stimulation by model antigens encoded by a recombinant suicide vector based on the Semliki Forest Virus (rSFV)

• despite the failure of B lymphocyte response to T cell-dependent antigen stimulation, FACS analysis of blood from the index mouse demonstrated normal frequencies of CD4⁺ T cells

decreased IgM level ( J:160882 )

• no detectable T cell-independent immunoglobulin M (IgM) response to haptenated Ficoll (TNP-Ficoll) stimulation

Genotype
MGI:5429188

hm2

• Allelic Composition: Irf4^m1Btlr/Irf4^m1Btlr
• Genetic Background: involves: C57BL/6J

immune system

immune system phenotype ( J:185495 )

N • mice exhibit normal peripheral blood lymphocytes

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization

hematopoietic system

abnormal class switch recombination ( J:185495 )

• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice

decreased IgG level ( J:185495 )

• response in response to recombinant Semliki Forest virus (SFV) encoded antigen

decreased IgM level ( J:185495 )

• following NP-Ficoll immunization