All Phenotypes Acd<tm1.1Cek> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Acd^tm1.1Cek
targeted mutation 1.1, Catherine Keegan
MGI:4456177

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acd^tm1.1Cek/Acd^tm1.1Cek	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * SJL	MGI:4456184

Allelic Composition	Acd^tm1.1Cek/Acd^tm1.1Cek
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6NCr * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acd^tm1.1Cek mutation (1 available); any Acd mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal chromosome morphology ( J:160503 )

• mouse embryonic fibroblasts expressing cre exhibit a 2.5- to 3.5-fold increase in single stranded telomeric DNA compared with wild-type cells

• some mouse embryonic fibroblasts expressing cre exhibit fusion of sister and non-sister telomeres unlike in wild-type cells

polyploidy ( J:160503 )

• mouse embryonic fibroblasts expressing cre undergo endoreduplication unlike wild-type cells

abnormal cell physiology ( J:160503 )

• mouse embryonic fibroblasts expressing cre exhibit a growth defect compared with wild-type cells

• in mouse embryonic fibroblasts expressing cre

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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