Phenotypes associated with this allele

• Allele Symbol: Plk3^tm1Pjs
• Allele Name: targeted mutation 1, Peter J Stambrook
• Allele ID: MGI:4456133
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plk3^tm1Pjs/Plk3^tm1Pjs	involves: 129S6/SvEvTac * Black Swiss	MGI:4456134

Genotype
MGI:4456134

hm1

• Allelic Composition: Plk3^tm1Pjs/Plk3^tm1Pjs
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

polyploidy ( J:175096 )

• in mouse embryonic fibroblasts following release from serum deprivation

abnormal cell cycle ( J:175096 )

• in mouse embryonic fibroblasts following release from serum deprivation

abnormal cell cycle checkpoint function ( J:175096 )

• in response to DNA damage, etoposide-treated cells exhibit defective G1/S checkpoint compared with wild-type cells

neoplasm

neoplasm ( J:175096 )

N • mice do not exhibit abnormal tumorigenesis