All Phenotypes Pnn<tm1.2Sps> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pnn^tm1.2Sps
targeted mutation 1.2, Stephen P Sugrue
MGI:4455342

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnn^tm1.2Sps/Pnn^tm1.2Sps	involves: 129S4/SvJae * C57BL/6	MGI:4455343
ht2	Pnn^tm1Sps/Pnn^tm1.2Sps	involves: 129S4/SvJae * C57BL/6	MGI:4455345
cn3	Pnn^tm1.1Sps/Pnn^tm1.2Sps Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S4/SvJae * FVB	MGI:4455346

Allelic Composition	Pnn^tm1.2Sps/Pnn^tm1.2Sps
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnn^tm1.2Sps mutation (0 available); any Pnn mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:123288 )

• slightly fewer embryos than expected are recovered at E3.5 and none are recovered after implantation

Allelic Composition	Pnn^tm1Sps/Pnn^tm1.2Sps
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnn^tm1.2Sps mutation (0 available); any Pnn mutation (31 available)
Pnn^tm1Sps mutation (0 available); any Pnn mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:123288 )

• embryos found at E9.5 are severely defective and do not appear to have undergone gastrulation

embryo

failure to gastrulate ( J:123288 )

• embryos found at E9.5 do not appear to have undergone gastrulation

failure of primitive streak formation ( J:123288 )

Allelic Composition	Pnn^tm1.1Sps/Pnn^tm1.2Sps Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background	involves: 129S4/SvJae * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnn^tm1.1Sps mutation (0 available); any Pnn mutation (31 available)
Pnn^tm1.2Sps mutation (0 available); any Pnn mutation (31 available)
Tg(Pax6-cre,GFP)1Pgr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:160411 )

N	• no changes in proliferation or apoptosis are detected in the eye

irregularly shaped pupil ( J:160411 )

abnormal cornea morphology ( J:160411 )

• severely disorganized

• accumulation of mesenchymal and vascular cells in the posterior area of the cornea

• expression analysis indicates squamous metaplasia with loss of specific corneal epithelial identity

abnormal cornea stroma morphology ( J:160411 )

• increased cellularity and abnormal cellular arrangements at E14.5

abnormal lens morphology ( J:160411 )

• lens degeneration

microphthalmia ( J:160411 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24