All Phenotypes Pnn<tm1.2Sps> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pnn^tm1.2Sps
targeted mutation 1.2, Stephen P Sugrue
MGI:4455342

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnn^tm1.2Sps/Pnn^tm1.2Sps	involves: 129S4/SvJae * C57BL/6	MGI:4455343
ht2	Pnn^tm1Sps/Pnn^tm1.2Sps	involves: 129S4/SvJae * C57BL/6	MGI:4455345
cn3	Pnn^tm1.1Sps/Pnn^tm1.2Sps Tg(Pax6-cre,GFP)1Pgr/0	involves: 129S4/SvJae * FVB	MGI:4455346

Allelic Composition	Pnn^tm1.2Sps/Pnn^tm1.2Sps
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnn^tm1.2Sps mutation (0 available); any Pnn mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:123288 )

• slightly fewer embryos than expected are recovered at E3.5 and none are recovered after implantation

Allelic Composition	Pnn^tm1Sps/Pnn^tm1.2Sps
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnn^tm1.2Sps mutation (0 available); any Pnn mutation (31 available)
Pnn^tm1Sps mutation (0 available); any Pnn mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:123288 )

• embryos found at E9.5 are severely defective and do not appear to have undergone gastrulation

embryo

failure to gastrulate ( J:123288 )

• embryos found at E9.5 do not appear to have undergone gastrulation

failure of primitive streak formation ( J:123288 )

Allelic Composition	Pnn^tm1.1Sps/Pnn^tm1.2Sps Tg(Pax6-cre,GFP)1Pgr/0
Genetic Background	involves: 129S4/SvJae * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnn^tm1.1Sps mutation (0 available); any Pnn mutation (31 available)
Pnn^tm1.2Sps mutation (0 available); any Pnn mutation (31 available)
Tg(Pax6-cre,GFP)1Pgr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:160411 )

N	• no changes in proliferation or apoptosis are detected in the eye

irregularly shaped pupil ( J:160411 )

abnormal cornea morphology ( J:160411 )

• severely disorganized

• accumulation of mesenchymal and vascular cells in the posterior area of the cornea

• expression analysis indicates squamous metaplasia with loss of specific corneal epithelial identity

abnormal cornea stroma morphology ( J:160411 )

• increased cellularity and abnormal cellular arrangements at E14.5

abnormal lens morphology ( J:160411 )

• lens degeneration

microphthalmia ( J:160411 )

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