Analysis Tools
mortality/aging
|
• all die at perinatal or late gestational stages
|
cardiovascular system
|
• ventricular septal defects associated with outflow tract abnormalities are seen in about 50% of mice
|
|
• ventricular septal defects associated with outflow tract abnormalities are seen in about 50% of mice
|
embryo
|
• mild
|
adipose tissue
|
• many embryos lack BAT on the dorsal aspect of the thorax
|
homeostasis/metabolism
|
• embryos appear edematous with subepidermal swellings on their dorsal areas from E13.5 onwards
|
skeleton
|
• fusion and irregular arrangement of vertebrosternal ribs
|
rib fusion
(
J:123288
)
|
• fusion of the vertebrosternal ribs
|
|
• lumbar to thoracic transformation of the 21st vertebra is seen
|
craniofacial
cleft palate
(
J:123288
)
|
• seen in about 30% of mice
|
digestive/alimentary system
cleft palate
(
J:123288
)
|
• seen in about 30% of mice
|
growth/size/body
cleft palate
(
J:123288
)
|
• seen in about 30% of mice
|
|
• mild
|
integument
| N |
• unlike the dermis, no obvious defects are seen in the epidermis
|
|
• in the dorsal area at E15.5
|
|
• disorganized dorsal dermis at E15.5
|
|
• thin dorsal dermis at E15.5
|
