Phenotypes associated with this allele

• Allele Symbol: Erbb3^m3329Ddg
• Allele Name: mutation 3329, David D Ginty
• Allele ID: MGI:4455202
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb3^m3329Ddg/Erbb3^m3329Ddg	involves: C3H/He * C57BL/6	MGI:4455314
hm2	Erbb3^m3329Ddg/Erbb3^m3329Ddg	involves: C57BL/6	MGI:4455312
ht3	Erbb3^m3329Ddg/Erbb3^tm1Gne	involves: 129S2/SvPas * C57BL/6	MGI:4455313

Genotype
MGI:4455314

hm1

• Allelic Composition: Erbb3^m3329Ddg/Erbb3^m3329Ddg
• Genetic Background: involves: C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system morphology ( J:159834 )

• mice exhibit abnormal development and patterning of the peripheral nervous system compared with wild-type mice

abnormal axon fasciculation ( J:159834 )

• mice exhibit defasciculation of all major peripheral branches of the dorsal root ganglia compared with wild-type mice

abnormal dorsal root ganglion morphology ( J:159834 )

• mice exhibit defasciculation of all major peripheral branches of the dorsal root ganglia compared with wild-type mice

• secondary and tertiary branches are absent unlike in wild-type mice

• axonal projections are splayed out almost randomly within the dermatome unlike in wild-type mice

cellular

abnormal axon fasciculation ( J:159834 )

• mice exhibit defasciculation of all major peripheral branches of the dorsal root ganglia compared with wild-type mice

Genotype
MGI:4455312

hm2

• Allelic Composition: Erbb3^m3329Ddg/Erbb3^m3329Ddg
• Genetic Background: involves: C57BL/6

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:160880 )

• while present in Mendelian ratio at E11.5, only one mouse was found at E14.5 and no mice are present at P0

prenatal lethality, complete penetrance ( J:160880 )

• while present in Mendelian ratio at E11.5, only one mouse was found at E14.5 and no mice are present at P0

nervous system

abnormal axon fasciculation ( J:160880 )

• mice exhibit defasciculation of all the major peripheral branches of the dorsal root ganglia and the trigeminal and spinal nerves compared with wild-type mice

abnormal mandibular nerve morphology ( J:160880 )

• mice exhibit an almost complete loss of the mandibular branch of the trigeminal ganglia unlike in wild-type mice

abnormal ophthalmic nerve morphology ( J:160880 )

• mice exhibit defasciculation of the ophthalmic branch of the trigeminal ganglia compared with wild-type mice

abnormal dorsal root ganglion morphology ( J:160880 )

• mice exhibit defasciculation of all the major peripheral branches of the dorsal root ganglia compared with wild-type mice

• secondary and tertiary branches are absent with axonal projections splaying out randomly within the dermatome unlike in wild-type mice

abnormal spinal nerve morphology ( J:160880 )

• mice exhibit defasciculation of spinal nerves compared with wild-type mice

cellular

abnormal axon fasciculation ( J:160880 )

• mice exhibit defasciculation of all the major peripheral branches of the dorsal root ganglia and the trigeminal and spinal nerves compared with wild-type mice

Genotype
MGI:4455313

ht3

• Allelic Composition: Erbb3^m3329Ddg/Erbb3^tm1Gne
• Genetic Background: involves: 129S2/SvPas * C57BL/6

nervous system

abnormal axon fasciculation ( J:160880 )

• mice exhibit the same defasciculation in trigeminal and spinal nerves observed in either single homozygote

abnormal trigeminal nerve morphology ( J:160880 )

• mice exhibit the same defasciculation in the trigeminal nerve observed in either single homozygote

abnormal spinal nerve morphology ( J:160880 )

• mice exhibit the same defasciculation in spinal nerves observed in either single homozygote

cellular

abnormal axon fasciculation ( J:160880 )

• mice exhibit the same defasciculation in trigeminal and spinal nerves observed in either single homozygote