Phenotypes associated with this allele

• Allele Symbol: Tg(H2-K^b-IL21)5Wjl
• Allele Name: transgene insertion 5, Warren J Leonard
• Allele ID: MGI:4454683
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(H2-K^b-IL21)5Wjl/0	involves: 129	MGI:4454775

Genotype
MGI:4454775

tg1

• Allelic Composition: Tg(H2-K^b-IL21)5Wjl/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell apoptosis ( J:93740 )

abnormal B cell differentiation ( J:93740 )

• B cell differentiation is driven towards postswitch cells unlike in wild-type mice

abnormal class switch recombination ( J:93740 )

• mice exhibit an increase in Ig class-switched B cells compared to in wild-type mice

decreased transitional stage T2 B cell number ( J:93740 )

increased immature B cell number ( J:93740 )

• in the periphery

increased transitional stage T1 B cell number ( J:93740 )

decreased mature B cell number ( J:93740 )

decreased follicular B cell number ( J:93740 )

decreased marginal zone B cell number ( J:93740 )

increased IgG1 level ( J:93740 )

increased IgM level ( J:93740 )

hematopoietic system

increased B cell apoptosis ( J:93740 )

abnormal B cell differentiation ( J:93740 )

• B cell differentiation is driven towards postswitch cells unlike in wild-type mice

abnormal class switch recombination ( J:93740 )

• mice exhibit an increase in Ig class-switched B cells compared to in wild-type mice

decreased transitional stage T2 B cell number ( J:93740 )

increased immature B cell number ( J:93740 )

• in the periphery

increased transitional stage T1 B cell number ( J:93740 )

decreased mature B cell number ( J:93740 )

decreased follicular B cell number ( J:93740 )

decreased marginal zone B cell number ( J:93740 )

increased IgG1 level ( J:93740 )

increased IgM level ( J:93740 )

cellular

increased B cell apoptosis ( J:93740 )