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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adamts4tm1Dqp
targeted mutation 1, Duanqing Pei
MGI:4454664
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adamts4tm1Dqp/Adamts4tm1Dqp involves: 129X1/SvJ * C57BL/6J MGI:5007491


Genotype
MGI:5007491
hm1
Allelic
Composition		 Adamts4tm1Dqp/Adamts4tm1Dqp
Genetic
Background		 involves: 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adamts4tm1Dqp mutation (0 available); any Adamts4 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Abnormal Purkinje cell morphology in the Sparcl1tm1Pmc/Sparcl1tm1Pmc and Adamts4tm1Dqp/Adamts4tm1Dqp cerebellum

nervous system
gliosis ( J:159752 )
• mice exhibit an increase in glial cells compared to in wild-type mice
abnormal Purkinje cell morphology ( J:159752 )
• mice exhibit stunted and less branched processes extending from extending from Purkinje cell bodies compared to in wild-type mice

cellular
gliosis ( J:159752 )
• mice exhibit an increase in glial cells compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory