Phenotypes associated with this allele

• Allele Symbol: Tshr^hyt-2J
• Allele Name: hypothyroid 2 Jackson
• Allele ID: MGI:4453218
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tshr^hyt-2J/Tshr^hyt-2J	B6;129P3-Tshr^hyt-2J/GrsrJ	MGI:5582803

Genotype
MGI:5582803

hm1

• Allelic Composition: Tshr^hyt-2J/Tshr^hyt-2J
• Genetic Background: B6;129P3-Tshr^hyt-2J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:213054 )

• the weight of homozygotes is approximately 60-70% that of wild type siblings

cellular

maternal effect ( J:213054 )

• auditory brainstem response shows hearing impairment in homozygous pups from homozygous mothers more than in homozygous pups from heterozygous mothers

homeostasis/metabolism

decreased circulating thyroxine level ( J:213054 )

• at 3 and 8 weeks of age homozygotes have serum thyroxine levels below 0.3 ug/dl

reproductive system

reproductive system phenotype ( J:213054 )

N • some homozygotes permitted extra time to mature have reproduced without hormonal intervention

endocrine/exocrine glands

increased thyrotroph cell number ( J:213054 )

• homozygotes have hyperplasia of the pituitary cells that produce thyroid stimulating hormone

abnormal thyroid follicle morphology ( J:213054 )

• the thyroid follicular epithelium is thin with little cytoplasm, and there are many empty follicles, although the thyroid is not abnormally small

nervous system

increased thyrotroph cell number ( J:213054 )

• homozygotes have hyperplasia of the pituitary cells that produce thyroid stimulating hormone

vision/eye

decreased b-wave amplitude ( J:213054 )

• detected as early as 15 weeks of age

abnormal cone electrophysiology ( J:213054 )

• low cone amplitude is found as early as 8 weeks of age

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:213054 )

• hearing loss is found by 6 weeks of age, the earliest time point assessed, and is more likely in homozyogtes from homozygous mothers than from heterozgyous mothers