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Allele Symbol Allele Name Allele ID |
Ptch1tm1Cklr targeted mutation 1, Charles Keller MGI:4453152 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival
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• earlier tumor onset, from 32 to 65 days of age
• bortezomib treated mice have better survival
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 9 of 30 double heterozygous mice become ataxic starting around 88-100 days of age
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• all ataxic mice have rapidly growing tumors in the cerebellum
• high nuclear to cytoplasm ratio in tumor cells
• tumors invade the subarachnoid space
• evidence of leptomeningeal metastasis
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• all ataxic mice have rapidly growing tumors in the cerebellum
• high nuclear to cytoplasm ratio in tumor cells
• tumors invade the subarachnoid space
• evidence of leptomeningeal metastasis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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