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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cldn2tm1Muto
targeted mutation 1, Shigeaki Muto
MGI:4452519
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cldn2tm1Muto/Cldn2tm1Muto involves: 129S4/SvJae * C57BL/6 MGI:4452521


Genotype
MGI:4452521
hm1
Allelic
Composition
Cldn2tm1Muto/Cldn2tm1Muto
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cldn2tm1Muto mutation (0 available); any Cldn2 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• no gross morphological malformations in kidney
• increased fractional excretion of NaCl in response to the NaCl challenge (i.v. administration of 2% NaCl at 20 ml/kg per hour)
• increased fractional excretion of calcium with free access to water and food
• decreased osmolality with free access to water and food
• normal daily water or food intake
• normal body weight
• increased transepithelial electrical resistance in proximal tubules
• increased (2.5-fold) in paracellular shunt resistance (RS) in proximal tubules
• transepithelial voltage deflects markedly toward the negative when abruptly chang the luminal perfusate to the low NaCl solution in isolated perfused S2 segments of proximal tubules
• reduced relative permeability of Na+ to Cl- (PNa/PCl) when abruptly chang the luminal perfusate to the low NaCl solution in isolated perfused S2 segments of proximal tubules
• lower relative permeabilities of the other cations (K+, Rb+, Na+, Li+ and choline+) in proximal tubules than those in wild-type
• normal relative permeabilities of the other anions
• decreased net transepithelial reabsorption of water in proximal tubules
• decreased net transepithelial reabsorption of NaCl in proximal tubules
• increased daily urine volume with free access to water and food

homeostasis/metabolism
• decreased net transepithelial reabsorption of water in proximal tubules
• decreased net transepithelial reabsorption of NaCl in proximal tubules
• increased fractional excretion of NaCl in response to the NaCl challenge (i.v. administration of 2% NaCl at 20 ml/kg per hour)
• increased fractional excretion of calcium with free access to water and food
• decreased osmolality with free access to water and food
• normal daily water or food intake
• normal body weight





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory