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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(CD19-Tnfsf7)#Rvl
transgene insertion, Rene A W van Lier
MGI:4452498
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Cd27tm1Jbo/Cd27tm1Jbo
Tg(CD19-Tnfsf7)#Rvl/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3716179
cx2
Tcratm1Mom/Tcratm1Mom
Tg(CD19-Tnfsf7)#Rvl/0
involves: 129P2/OlaHsd * C57BL/6 MGI:3716180
tg3
Tg(CD19-Tnfsf7)#Rvl/0 involves: C57BL/6 MGI:3716170


Genotype
MGI:3716179
cx1
Allelic
Composition
Cd27tm1Jbo/Cd27tm1Jbo
Tg(CD19-Tnfsf7)#Rvl/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd27tm1Jbo mutation (1 available); any Cd27 mutation (29 available)
Tg(CD19-Tnfsf7)#Rvl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• B cell numbers are normal




Genotype
MGI:3716180
cx2
Allelic
Composition
Tcratm1Mom/Tcratm1Mom
Tg(CD19-Tnfsf7)#Rvl/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mom mutation (6 available); any Tcra mutation (97 available)
Tg(CD19-Tnfsf7)#Rvl mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• spleens lack T cells

immune system
• spleens lack T cells




Genotype
MGI:3716170
tg3
Allelic
Composition
Tg(CD19-Tnfsf7)#Rvl/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• transitional-1 B cells are reduced at 4 weeks of age and declining over time
• transitional-2 B cells decline after 6 to 8 weeks
• mature B cells are reduced at 4 weeks of age and declining over time
• marginal metallophilic macrophages decline more gradually than marginal zone macrophages
• B cell follicles are reduced in size
• marginal zone macrophages decline in number at 5 weeks

immune system
• transitional-1 B cells are reduced at 4 weeks of age and declining over time
• transitional-2 B cells decline after 6 to 8 weeks
• mature B cells are reduced at 4 weeks of age and declining over time
• marginal metallophilic macrophages decline more gradually than marginal zone macrophages
• B cell follicles are reduced in size
• marginal zone macrophages decline in number at 5 weeks





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory