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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Prnp-ITM2B*)6Jckr
transgene insertion 6, Mathias Jucker
MGI:4452484
Summary 2 genotypes


Genotype
MGI:4452490
cx1
Allelic
Composition		 Tg(Prnp-ITM2B*)6Jckr/0
Tg(Thy1-APP)3Somm/0
Genetic
Background		 B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Prnp-ITM2B*)6Jckr mutation (0 available)
Tg(Thy1-APP)3Somm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
amyloid beta deposits ( J:159279 )
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice

homeostasis/metabolism
amyloidosis ( J:159279 )
• mice exhibit an accumulation of Dan-amyloid in separate plaques from amyloid beta plaques
amyloid beta deposits ( J:159279 )
• at 13 months, mice exhibit a 70% reduction in neocortical amyloid beta deposition compared with Tg(Thy1-APP)3Somm mice




Genotype
MGI:4452493
tg2
Allelic
Composition		 Tg(Prnp-ITM2B*)6Jckr/0
Genetic
Background		 C57BL/6-Tg(Prnp-ITM2B*)6Jckr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
amyloidosis ( J:159279 )
• at 12 months, mice exhibit a 3- to 4-fold increase in Tau lesions compared with Tg(Thy1-MAPT*P301S)2541Godt mice




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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory