About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sbdstm1Dats
targeted mutation 1, David T Scadden
MGI:4452398
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sbdstm1Dats/Sbdstm1Dats
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 		involves: C57BL/6 * CD-1 MGI:4452404


Genotype
MGI:4452404
cn1
Allelic
Composition		 Sbdstm1Dats/Sbdstm1Dats
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background		 involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sbdstm1Dats mutation (0 available); any Sbds mutation (31 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
impaired hematopoiesis ( J:158901 )
• mice exhibit intrameduallry apoptosis of hematopoeitic progenitor cells unlike in wild-type mice
abnormal megakaryocyte morphology ( J:158901 )
• micro-megakaryocytes
decreased lymphocyte cell number ( J:158901 )
• but not neutropenia
decreased B cell number ( J:158901 )
• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice
abnormal myeloid leukocyte morphology ( J:158901 )
• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice

skeleton
abnormal bone structure ( J:158901 )
• texture of mineralized is altered compared to in wild-type mice
abnormal bone marrow morphology ( J:158901 )
• bone marrow vascularity is increased compared to in wild-type mice

cardiovascular system
abnormal cardiovascular system morphology ( J:158901 )
• bone marrow vascularity is increased compared to in wild-type mice

immune system
decreased lymphocyte cell number ( J:158901 )
• but not neutropenia
decreased B cell number ( J:158901 )
• B cell and B cell progenitors are decreased in the bone marrow compared to in wild-type mice
abnormal myeloid leukocyte morphology ( J:158901 )
• myeloid cell frequency is increased in the bone marrow compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory