Phenotypes associated with this allele

• Allele Symbol: Pglyrp2^tm1Lky
• Allele Name: targeted mutation 1, Richard M Locksley
• Allele ID: MGI:4452065
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pglyrp2^tm1Lky/Pglyrp2^tm1Lky	involves: 129S4/SvJae * C57BL/6	MGI:4452067

Genotype
MGI:4452067

hm1

• Allelic Composition: Pglyrp2^tm1Lky/Pglyrp2^tm1Lky
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:159600 )

• death rate from peritoneal injection of 2 million viable E coli is less than in controls (40% vs 60%)

immune system

abnormal macrophage physiology ( J:159600 )

• macrophage produce less Il6 in response to LPS or heat killed E coli

• macrophage produce less TNF alpha in response to LPS

decreased circulating interleukin-6 level ( J:159600 )

• death rate from peritoneal injection of 2 million viable E coli is somewhat diminished

• macrophage produce less Il6 in response to LPS or heat killed E coli

abnormal tumor necrosis factor level ( J:159600 )

• macrophage produce less TNF alpha in response to LPS

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:159600 )

• death rate from peritoneal injection of 2 million viable E coli is less than in controls (40% vs 60%)

homeostasis/metabolism

decreased circulating interleukin-6 level ( J:159600 )

• death rate from peritoneal injection of 2 million viable E coli is somewhat diminished

• macrophage produce less Il6 in response to LPS or heat killed E coli

abnormal tumor necrosis factor level ( J:159600 )

• macrophage produce less TNF alpha in response to LPS

hematopoietic system

abnormal macrophage physiology ( J:159600 )

• macrophage produce less Il6 in response to LPS or heat killed E coli

• macrophage produce less TNF alpha in response to LPS