All Phenotypes Sall1<tm4.1Ryn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sall1^tm4.1Ryn
targeted mutation 4.1, Ryuichi Nishinakamura
MGI:4443121

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sall1^tm4.1Ryn/Sall1^tm4.1Ryn	involves: 129P2/OlaHsd	MGI:4454537
cn2	Sall1^{tm5(cre/ERT2)Ryn}/Sall1^tm4.1Ryn	involves: 129P2/OlaHsd	MGI:4818961
cn3	Sall1^tm4.1Ryn/Sall1^tm4.1Ryn Sall4^tm3Ryn/Sall4^tm4Ryn	involves: 129P2/OlaHsd	MGI:4454539

Allelic Composition	Sall1^tm4.1Ryn/Sall1^tm4.1Ryn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm4.1Ryn mutation (2 available); any Sall1 mutation (77 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:159449 )

• mice are healthy and fertile

Allelic Composition	Sall1^{tm5(cre/ERT2)Ryn}/Sall1^tm4.1Ryn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm4.1Ryn mutation (2 available); any Sall1 mutation (77 available)
Sall1^{tm5(cre/ERT2)Ryn} mutation (0 available); any Sall1 mutation (77 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:159446 )

• mutants do not survive after birth with tamoxifen treatment on E12.5

renal/urinary system

abnormal kidney morphology ( J:159446 )

• tubular structures are reduced at E14.5

small kidney ( J:159446 )

• with i.p. tamoxifen delivery to pregnant dams on E12.5, kidney size is significantly reduced at E18.5

abnormal renal tubule morphology ( J:159446 )

• numbers of proximal and distale tubules are significantly reduced compared to controls, but glomerular development is not significantly affected

Allelic Composition	Sall1^tm4.1Ryn/Sall1^tm4.1Ryn Sall4^tm3Ryn/Sall4^tm4Ryn
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall1^tm4.1Ryn mutation (2 available); any Sall1 mutation (77 available)
Sall4^tm3Ryn mutation (0 available); any Sall4 mutation (144 available)
Sall4^tm4Ryn mutation (0 available); any Sall4 mutation (144 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased cell proliferation ( J:159449 )

• embryonic stem cells treated with cre-expressing adenovirus exhibit impaired proliferation compared with wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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