Phenotypes associated with this allele

• Allele Symbol: Slc7a11^m1Mtka
• Allele Name: mutation 1, Masato Tanaka
• Allele ID: MGI:4442905
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc7a11^m1Mtka/Slc7a11^m1Mtka	C57BL/6-Slc7a11^m1Mtka	MGI:4442909

Genotype
MGI:4442909

hm1

• Allelic Composition: Slc7a11^m1Mtka/Slc7a11^m1Mtka
• Genetic Background: C57BL/6-Slc7a11^m1Mtka

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:159323 )

N • steady-state homeostasis of macrophages and dendritic cells is normal

abnormal macrophage physiology ( J:159323 )

• LPS-stimulated macrophages exhibit decreased survival compared with similarly treated wild-type cells

• however, decreased survival is not due to increased apoptosis

abnormal dendritic cell physiology ( J:159323 )

• dendritic cells from E17.5 livers exhibit no proliferation in response to GM-CSF unlike similarly treated wild-type cells

• however, proliferation in the presence of 2-mercaptoethanol is normal

cellular

decreased fibroblast proliferation ( J:159323 )

• embryonic fibroblasts exhibit reduced proliferation compared with heterozygous cells

• however, proliferation in the presence of 2-mercaptoethanol is normal

neoplasm

increased incidence of tumors by chemical induction ( J:159323 )

• 3-MCA-treated mice develop tumors earlier than similarly treated wild-type mice

• however, tumor growth is normal

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:159323 )

• 3-MCA-treated mice develop tumors earlier than similarly treated wild-type mice

• however, tumor growth is normal

hematopoietic system

abnormal macrophage physiology ( J:159323 )

• LPS-stimulated macrophages exhibit decreased survival compared with similarly treated wild-type cells

• however, decreased survival is not due to increased apoptosis