Phenotypes associated with this allele

• Allele Symbol: Tap2^m1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:4442846
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tap2^m1Btlr/Tap2^m1Btlr	C57BL/6J-Tap2^m1Btlr	MGI:4442847

Genotype
MGI:4442847

hm1

• Allelic Composition: Tap2^m1Btlr/Tap2^m1Btlr
• Genetic Background: C57BL/6J-Tap2^m1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent CD8-positive, alpha-beta T cells ( J:159355 )

• homozygous mutant mice exhibit nearly complete absence of CD8⁺ T cells in the blood

abnormal NK cell physiology ( J:159355 )

• homozygous mutant mice fail to kill class I MHC-deficient target cells of natural killer (NK) cells in vivo

abnormal cytotoxic T cell physiology ( J:159355 )

• mice homozygous for this mutation fail to kill antigen-specific target cells of CD8⁺ cytotoxic T lymphocytes (CTL) in vivo

immune system

absent CD8-positive, alpha-beta T cells ( J:159355 )

• homozygous mutant mice exhibit nearly complete absence of CD8⁺ T cells in the blood

abnormal NK cell physiology ( J:159355 )

• homozygous mutant mice fail to kill class I MHC-deficient target cells of natural killer (NK) cells in vivo

abnormal cytotoxic T cell physiology ( J:159355 )

• mice homozygous for this mutation fail to kill antigen-specific target cells of CD8⁺ cytotoxic T lymphocytes (CTL) in vivo

decreased level of surface class I molecules ( J:159355 )

• lymphocytes of homozygous mutants lack surface presentation of MHC class I molecules

defective assembly of class I molecules ( J:159355 )