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Allele Symbol Allele Name Allele ID |
Fzd1tm1.1Nat targeted mutation 1.1, Jeremy Nathans MGI:4442608 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice are fertile
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| N |
• mice exhibit normal cardiac morphology
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| N |
• mice exhibit normal orofacial morphology
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• gray coat color
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• gray coat color
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 16 of 22 mice between E16 and E18 exhibit either ventricular septal defect (VSD), overriding aorta, double outlet right ventricle, or a combination of VSD and one of the other two defects unlike wild-type mice
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• at E16, the roof of the mouth is wider than in wild-type mice
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• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
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• in nearly all mice
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• in some mice
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| N |
• mice exhibit normal dorsal root ganglia and thymic rudiments indicating normal neural crest migration
• mice do not exhibit neural tube defects
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• mice exhibit cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) unlike wild-type mice
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• most severe in outer hair cell row 3
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• mice exhibit cochlear hair cell defects (hair cell number and outer hair cell row 3 orientation) unlike wild-type mice
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• most severe in outer hair cell row 3
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• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
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• in nearly all mice
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• in some mice
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• at E16, the roof of the mouth is wider than in wild-type mice
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• at E13, the number of apoptotic cells is increased 2-fold compared to in wild-type mice likely as a secondary consequence to failure of palate shelf movement
• however, proliferation of cells during palate development is normal
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• in nearly all mice
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• in some mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 1 of 8 mice
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• in 2 of 208 mice
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• in 2 of 208 mice
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• in 2 of 208 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 12 of 27 mice, more common in the rostral neural tube
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• muscular and/or membranous in mice with neural tube defects
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• in 12 of 27 mice, more common in the rostral neural tube
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in 4 of 7 mice, more common in the rostral neural tube
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• muscular and/or membranous in mice with neural tube defects
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• in 4 of 7 mice, more common in the rostral neural tube
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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