Phenotypes associated with this allele

• Allele Symbol: Il25^tm1.1Cdon
• Allele Name: targeted mutation 1.1, Chen Dong
• Allele ID: MGI:4442365
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il25^tm1.1Cdon/Il25^tm1.1Cdon	involves: 129S6/SvEvTac	MGI:4442372
cx2	Il17b^Gt(371C12)Cmhd/Il17b^Gt(371C12)Cmhd Il25^tm1.1Cdon/Il25^tm1.1Cdon	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:5767209

Genotype
MGI:4442372

hm1

• Allelic Composition: Il25^tm1.1Cdon/Il25^tm1.1Cdon
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to induced colitis ( J:229778 )

• DSS-treated mice exhibit reduced weight loss, colonic inflammation and colon length shortening with protection from inflammatory destruction, tissue remodeling and leukocyte infiltration compared with wild-type mice

decreased eosinophil cell number ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

decreased T-helper 2 cell number ( J:229778 )

• upon ovalbumin restimulation in mice treated with ovalbumin and alum to induce asthma

increased susceptibility to type I hypersensitivity reaction ( J:158594 )

• fewer infiltrating inflammatory cells in the bronchoalveolar lavage fluid after repeated intranasal allergen challenge with the Aspergillus oryzae protease and OVA protein

abnormal chemokine secretion ( J:229778 )

• reduced CCL2 in the colon tissue of DDS-treated mice compared with wild-type mice

abnormal interleukin secretion ( J:229778 )

• decreased IL22 in colon tissue of C. rodentium-infected mice

decreased interleukin-1 beta secretion ( J:229778 )

• in the colon tissue of DDS-treated mice

decreased interleukin-13 secretion ( J:158594 , J:229778 )

• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge, where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27 (J:158594)

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma (J:229778)

decreased interleukin-4 secretion ( J:158594 , J:229778 )

• in the bronchoalveolar lavage fluid after repeated allergen challenge (J:158594)

• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge, where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27 (J:158594)

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma (J:229778)

decreased interleukin-5 secretion ( J:158594 , J:229778 )

• in the bronchoalveolar lavage fluid after repeated allergen challenge (J:158594)

• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge, where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27 (J:158594)

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma (J:229778)

decreased interleukin-9 secretion ( J:158594 )

• in draining lymph nodes and bronchoalveolar lavage 24 hrs after last challenge , where mice were sensitized with OVA in alum at day 0 and 14, followed by intranasal challenge with OVA at day 14, 25, 26 and 27

decreased tumor necrosis factor secretion ( J:229778 )

• in the colon tissue of DDS-treated mice

lung inflammation ( J:158594 )

• fewer infiltrating inflammatory cells in the bronchoalveolar lavage fluid after repeated intranasal allergen challenge with the Aspergillus oryzae protease and OVA protein

decreased susceptibility to bacterial infection ( J:229778 )

• Citrobacter rodentium-infected mice exhibit reduced weight loss and fecal bacteria compared with wild-type mice

respiratory system

lung inflammation ( J:158594 )

• fewer infiltrating inflammatory cells in the bronchoalveolar lavage fluid after repeated intranasal allergen challenge with the Aspergillus oryzae protease and OVA protein

growth/size/body

decreased susceptibility to weight loss ( J:229778 )

• in DSS-treated mice

• Citrobacter rodentium-infected mice exhibit reduced weight loss compared with wild-type mice

digestive/alimentary system

abnormal colon morphology ( J:229778 )

• reduced DSS-induced colon shortening compared with wild-type mice

decreased susceptibility to induced colitis ( J:229778 )

• DSS-treated mice exhibit reduced weight loss, colonic inflammation and colon length shortening with protection from inflammatory destruction, tissue remodeling and leukocyte infiltration compared with wild-type mice

hematopoietic system

decreased eosinophil cell number ( J:229778 )

• in bronchoalveolar lavage fluid of mice treated with ovalbumin and alum to induce asthma

decreased T-helper 2 cell number ( J:229778 )

• upon ovalbumin restimulation in mice treated with ovalbumin and alum to induce asthma

Genotype
MGI:5767209

cx2

• Allelic Composition: Il17b^{Gt(371C12)Cmhd}/Il17b^{Gt(371C12)Cmhd}; Il25^tm1.1Cdon/Il25^tm1.1Cdon
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

immune system

immune system phenotype ( J:229778 )

N • unlike either single homozygote, DSS-treated mice exhibit normal weight loss and colon inflammation

N • Citrobacter rodentium-infected mice exhibit normal IL22 in colon tissue

N • mice treated with ovalbumin and alum to induce asthma exhibit normal Th2 cell cytokine production

digestive/alimentary system

digestive/alimentary phenotype ( J:229778 )

N • unlike either single homozygote, DSS-treated mice exhibit normal weight loss and colon inflammation