Phenotypes associated with this allele

• Allele Symbol: Chd6^tm1.2Fier
• Allele Name: targeted mutation 1.2, Steven Fiering
• Allele ID: MGI:4442238
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chd6^tm1.2Fier/Chd6^tm1.2Fier	129S1/SvImJ-Chd6^tm1.2Fier	MGI:4442242
hm2	Chd6^tm1.2Fier/Chd6^tm1.2Fier	involves: 129S1/SvImJ * BALB/c * C57BL/6	MGI:4442240

Genotype
MGI:4442242

hm1

• Allelic Composition: Chd6^tm1.2Fier/Chd6^tm1.2Fier
• Genetic Background: 129S1/SvImJ-Chd6^tm1.2Fier

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:158513 )

N • Background Sensitivity: unlike mice on a mixed 129S1/SvImJ, BALB/c, and C57BL/6 background, mice on a coisogenic 129S1/SvImJ background do not display a defect in their ability to walk across a narrow cylindrical beam

N • Background Sensitivity: unlike mice on a mixed 129S1/SvImJ, BALB/c, and C57BL/6 background, mice on a coisogenic 129S1/SvImJ do not display a decrease in the ratio of center to wall time compared with wild-type

impaired coordination ( J:158513 )

• Background Sensitivity: unlike mice on a mixed 129S1/SvImJ, BALB/c, and C57BL/6 background mice progress normally in a ledge test; however, they fail to climb into cage in a controlled manner

• 10 and 20 week old mice fall off a rotarod significantly earlier than wild-type

Genotype
MGI:4442240

hm2

• Allelic Composition: Chd6^tm1.2Fier/Chd6^tm1.2Fier
• Genetic Background: involves: 129S1/SvImJ * BALB/c * C57BL/6

behavior/neurological

increased thigmotaxis ( J:158513 )

• Background Sensitivity: mice on a mixed background, but not mice on a coisogenic 129S1/SvImJ, display slightly decreased ratio of center to wall time compared with wild-type however, no increase in anxiety related behavior is detected in a Barnes maze assay

abnormal motor capabilities/coordination/movement ( J:158513 )

• Background Sensitivity: most mice fail to cross a cylindrical beam, instead mice jump off at the start location, this behavior is not seen in mice on a coisogenic 129S1/SvImJ background

• this abnormality does not appear to be the result of a defect in olfactory capability

impaired coordination ( J:158513 )

• mice fall off a rotarod significantly earlier than wild-type

• fewer mice enter the goal box in a Barnes maze; this defect is not due to impaired spatial learning or increased anxiety

• Background Sensitivity: most mice do not progress on a ledge test unlike wild-type mice or mice on a coisogenic 129S1/SvImJ background