Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3tm1.1Hwrt mutation
(1 available);
any
Chrna3 mutation
(32 available)
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mortality/aging
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• Background Sensitivity: all mice on a C57BL/6 inbred background are dead by 3 months of age of unknown causes unlike on an outbred background
• Background Sensitivity: less than 2% of mice on a C57BL/6 inbred background survive at P70 compared to 60% on an outbred background
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• 50% of mice on a C57BL/6 inbred background die prior to 1 to 2 weeks of age unlike on outbred backgrounds
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growth/size/body
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• Background Sensitivity: mice are runted on a C57BL/6 inbred background unlike normal-sized mice on a mixed background containing BALB/c
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renal/urinary system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3tm1.1Hwrt mutation
(1 available);
any
Chrna3 mutation
(32 available)
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mortality/aging
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• Background Sensitivity: 60% of mice survive at P70 on a mixed background compared to less than 2% on a C57BL/6 inbred background
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growth/size/body
N |
• Background Sensitivity: mice are of normal size on a mixed background containing BALB/c unlike runted mice on a C57BL/6 inbred background
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3tm1.1Hwrt mutation
(1 available);
any
Chrna3 mutation
(32 available)
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mortality/aging
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• average lifespan is similar to on a mixed background containing ICR
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nervous system
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• nerve-evoked compound action potentials (CAPs) from the postganglionic trunk in the superior cervical ganglia are smaller than in wild-type mice
• nerve-evoked CAPs are completely blocked by alpha-bungarotoxin unlike in wild-type mice
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• most nerve-evoked excitatory postsynaptic potentials (EPSPs) on sympathetic neurons in the superior cervical ganglia are subthreshold compared to in wild-type mice
• unlike in wild-type mice, nerve evoked EPSPs are blocked by alpha-bungarotoxin
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna3tm1.1Hwrt mutation
(1 available);
any
Chrna3 mutation
(32 available)
|
|
|
mortality/aging
|
• Background Sensitivity: average lifespan is 5 months on an outbred background compared with less than 3 month on a C57BL/6 inbred background
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nervous system
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• most nerve-evoked excitatory postpynaptic potentials (EPSPs) on sympathetic neurons in the superior cervical ganglia are subthreshold compared to in wild-type mice
• unlike in wild-type mice, nerve evoked EPSPs are blocked by alpha-bungarotoxin
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