Analysis Tools
nervous system
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• at P84, brain surface area of the left hemisphere is ~5% smaller than that in heterozygous controls
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• at P0, lateral ventricle area of the right hemisphere is significantly larger than that in wild-type controls
• at P84, lateral ventricle area of the left hemisphere is ~95% larger than that in heterozygous controls
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• at P0, cortex surface area (right hemisphere only) is on average ~5% smaller than that in wild-type controls
• at P84, cortex surface area is ~8% smaller than that in heterozygous controls
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• at P0, cortical thickness is on average ~14% thinner than that in wild-type controls
• at P84, cortical thickness (from the edge of the hippocampus to the outer cortex) is significantly reduced relative to that in heterozygous controls
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behavior/neurological
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• adult homozygotes show no differences in spontaneous locomotor activity, rotarod performance, or anxiety-like behavior in the light-dark emergence test relative to heterozygous controls
• adult homozygotes show no evidence of behavioral or electrographic seizures, similar to wild-type controls
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• adult homozygotes are severely impaired in long-term memory in the novel object recognition task; they continue to show no object preference and significantly lower preference scores than heterozygous or wild-type controls
• however, time spent exploring the objects or total investigative contacts with the objects are not significantly altered
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• adult homozygotes are severely impaired in short-term memory in the novel object recognition task and show significantly lower preference scores for the novel object than wild-type controls
• however, time spent exploring the objects or total investigative contacts with the objects are not significantly altered
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