All Phenotypes Ddx11<tm1Jiml> MGI Mouse

• no mice are recovered at or beyond E11.5

increased allantois apoptosis ( J:158490 )

• extensive apoptosis is detected in the residual allantois unlike in wild-type mice

abnormal embryo development ( J:158490 )

• embryo cellularity is very sparse compared with wild-type mice

• however, a body axis does form

embryonic growth arrest ( J:185600 )

• arrest between E7.5 and E8.5

embryonic growth retardation ( J:158490 )

• at E7.5 and more discernibly between E9.5 and E10.5

decreased embryo size ( J:185600 )

absent paraxial mesoderm ( J:185600 )

• absence of somitic mesoderm

kinked neural tube ( J:185600 )

absent somites ( J:185600 )

• cultured blastocyst fail to differentiate unlike wild-type cells

• at E9.5, embryos exhibit increased apoptosis compared with wild-type mice (J:158490)

• dramatic increase in the number of apoptotic cells in the embryo at E7.5 (J:185600)

• apoptotic cells are evenly distributed in the epithelia, mesoderm, and endoderm (J:185600)

• mild growth retardation in culture

placental labyrinth hypoplasia ( J:158490 )

• at E10.5

failure of chorioallantoic fusion ( J:158490 )

• at E9.5

aneuploidy ( J:158490 )

• in 43% of cells from E9.5 embryos

abnormal cell cycle ( J:158490 )

• at E8.5 and E10.5, embryos exhibit mild delay in G2/M cell cycle compared with wild-type mice