Phenotypes associated with this allele

• Allele Symbol: Ptgs2^tm2.1Hahe
• Allele Name: targeted mutation 2.1, Harvey R Herschman
• Allele ID: MGI:4440835
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ptgs2^tm1Unc/Ptgs2^tm2.1Hahe	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:4440882

Genotype
MGI:4440882

ht1

• Allelic Composition: Ptgs2^tm1Unc/Ptgs2^tm2.1Hahe
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:158426 )

• mice treated with azoxymethane and dextran sulfate sodium exhibit increased mortality compared with similarly treated wild-type mice

immune system

increased susceptibility to induced colitis ( J:158426 )

• mice treated with azoxymethane and dextran sulfate sodium exhibit increased mortality compared with similarly treated wild-type mice

neoplasm

neoplasm ( J:158426 )

N • mice treated with azoxymethane and dextran sulfate sodium exhibit wild-type colon tumor incidence and histology

digestive/alimentary system

increased susceptibility to induced colitis ( J:158426 )

• mice treated with azoxymethane and dextran sulfate sodium exhibit increased mortality compared with similarly treated wild-type mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:158426 )

• mice treated with azoxymethane and dextran sulfate sodium exhibit increased mortality compared with similarly treated wild-type mice