All Phenotypes Clic1<tm1.1Breit> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Clic1^tm1.1Breit
targeted mutation 1.1, Samuel Breit
MGI:4440469

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clic1^tm1.1Breit/Clic1^tm1.1Breit	involves: 129 * C57BL/6J	MGI:4440470

Allelic Composition	Clic1^tm1.1Breit/Clic1^tm1.1Breit
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Clic1^tm1.1Breit mutation (0 available); any Clic1 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal platelet activation ( J:158394 )

• decreased platelet activation

decreased platelet aggregation ( J:158394 )

• rate of ADP-stimulated platelet aggregation is about 40% lower

increased bleeding time ( J:158394 )

• about twice as long as controls

hematopoietic system

thrombocytosis ( J:158394 )

• 15% higher basal platelet count

abnormal platelet activation ( J:158394 )

• decreased platelet activation

decreased platelet aggregation ( J:158394 )

• rate of ADP-stimulated platelet aggregation is about 40% lower

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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